In-Vitro Gametogenesis (IVG) — Selection Multiplier
mechanismAI & Compute · Biotech & Transhumanism
Scientists can already make eggs from stem cells in mice, and if it ever works in humans it could let people screen thousands of embryos at once.
Who they are
In-Vitro Gametogenesis (IVG), a technique for making eggs and sperm from stem cells[1].[2][3]
What they do
It's lab-grown reproductive cells; in mice it has produced live healthy pups, but in humans it has only reached immature precursor cells, with no working human gametes and no human births yet.
How it works
The Hayashi lab produced mouse pups from stem-cell-derived eggs around 2016; human efforts (companies like Gameto and Conception Bio) have only made immature cells so far, and the worry is that IVG could break the natural limit on egg numbers and let embryo selection be done at industrial scale.
Why it matters
The engine holds the 'select from thousands of embryos' scale as a projected concern, not a fact, since human IVG isn't real yet; it also flags a proposed political misuse (state-directed 'embryo selection' for racial goals) as studied but not endorsed, naming no one as responsible.
The engine's record — word for word
[Report #108 — Cloning/Eugenics Lens] Making eggs/sperm from stem cells. Live, healthy mouse pups have been born from stem-cell-derived eggs (Hayashi lab, ~2016); human work has reached only immature precursors (oocyte-like cells, prospermatogonia) — NO functional human gametes, NO human births (companies: Gameto, Conception Bio). The recognized bioethics concern (peer-reviewed): IVG breaks the egg-number bottleneck and could industrialize embryo SELECTION — selecting from thousands rather than ~10. The specific 'thousands/10,000 embryos' scale is a PROJECTION contingent on human IVG (not yet achieved), held as a concern not a fact. Apex held; manifestation b. [Fact-checked Jun 17 2026.] [Report #133] Demand-side ideological instance (flagged-not-endorsed): Jason Jorjani's proposed state-directed eugenic 'embryo selection' to restore an 'Aryan/pre-Arab' genetic character (see jason_jorjani / genome_as_selection_substrate) is exactly the embryo-selection-at-scale this node flags as the IVG bioethics concern, framed as an explicit political demand. The claim is studied, not validated; held-not-endorsed; name no holder.
Report #181 (the extra-uterine limb, adjacent to this node's selection-multiplier thread): CHOP's EXTEND system (Flake/Partridge, 2017) gestated extreme-premature lamb fetuses ex utero up to 28 days — umbilical cannulation into a pumpless oxygenator circuit (fetal cardiac pressure drives flow), sterile synthetic amniotic fluid, no mechanical ventilation. FDA Pediatric Advisory Committee convened Sept 19-20 2023 on the human-trial horizon — the current gate is regulatory/ethical, not raw capability. An 'AI-driven biobag, thousands of data points per second' claim is blog-tier REPORTED-UNVERIFIED; peer-reviewed reviews describe AI integration as research direction.
Report #183 (2026 milestone): human iPSC-derived primordial-germ-cell-like cells self-organised into seminiferous-tubule-like structures in a xenogeneic reconstituted testis and yielded spermatogonia up to MEIOTIC ONSET (Cell Stem Cell, Aug 2026); the Saitou lab separately reconstituted sex determination and the testicular niche from mouse pluripotent cells (Science, Feb 2026). The selection-multiplier thread advances one step closer to gametes from cells. [AI & Bio-Selection Audit] Status refresh: the Hayashi lab has turned skin cells from male mice into eggs and bred live pups[4]; NO functional HUMAN gametes exist yet (Hayashi's own estimate: a human egg from skin cells 'within a decade'), with Conception Biosciences (Berkeley) among those pursuing it. The 'industrialize embryo selection' concern stays a projection contingent on human IVG, not a fact. Held; name no holder.
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